(Hyperthemia) 37.1 . (Energy) (Basal metabolism) , : , , . , , , . (Thermoregulation - ) , (Hypothalamus). , / . 41.6 .
1960 . 90% 60 5% , (Dantrolene ). ( ) , , . , 43-44 .





: (Arrhythmias) , / , (End tidal CO2), (Cyanosis), (hemodynamic collapse). , 5 , .





:
- : , , , .
- : Ⱥ ; .
, (neuroleptic malignant syndrome) .
- : (salicylate), (Cocaine), (Amphetamines) (Endocrine diseases): (Hyperthyroidism), - (Pheochromocytoma) (Status epilepticus).
- : (Autonomic neuropathy).
- : (Anticholinergic drugs) (Dehydration) .
- : , . , (Rhabdomyolysis), (Coagulation Disorders). . .
- (Malignant hyperthermia): , , ( - halothane, - Isoflurane, - Enflurane, - Desflurane - Sevoflurane) / (Depolarizing muscle relaxant) ( ) (succinylcholine), . , (Autosomal dominant) (chromosome 19), (Ryanodin receptor).






:
(Metabolic and Respiratory acidosis), (Creatine phosphokinase CPK), (Cardiac arrest), (Myoglobin - ) .






, , (Dantrolene), (antidote) (Pathologic). , 24 . (Muscle biopsy) , , 3-6 .