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الموضوع: Hemochromatosis

  1. #1
    عضو ذهبي الصورة الرمزية Maria Isa
    تاريخ التسجيل
    Apr 2012
    الدولة
    الاردن - صويلح
    المشاركات
    403

    افتراضي Hemochromatosis

    Hemochromatosis



    Hemochromatosis is the most common form of iron overload disease. Primary hemochromatosis, also called hereditary hemochromatosis, is an inherited disease. Secondary hemochromatosis is caused by anemia, alcoholism, and other disorders.
    Juvenile hemochromatosis and neonatal hemochromatosis are two additional forms of the disease. Juvenile hemochromatosis leads to severe iron overload and liver and heart disease in adolescents and young adults between the ages of 15 and 30. The neonatal form causes rapid iron buildup in a baby's liver that can lead to death.

    Hemochromatosis causes the body to absorb and store too much iron. The extra iron builds up in the body's organs and damages them. Without treatment, the disease can cause the liver, heart, and pancreas to fail.
    Iron is an essential nutrient found in many foods. The greatest amount is found in red meat and iron-fortified breads and cereals. In the body, iron becomes part of hemoglobin, a molecule in the blood that transports oxygen from the lungs to all body tissues.
    Healthy people usually absorb about 10 percent of the iron contained in the food they eat, which meets normal dietary requirements. People with hemochromatosis absorb up to 30 percent of iron. Over time, they absorb and retain between five to 20 times more iron than the body needs.
    Because the body has no natural way to rid itself of the excess iron, it is stored in body tissues, specifically the liver, heart, and pancreas.


    What causes hemochromatosis


    Hereditary hemochromatosis is mainly caused by a defect in a gene called HFE, which helps regulate the amount of iron absorbed from food. The two known mutations of HFE are C282Y and H63D. C282Y is the most important. In people who inherit C282Y from both parents, the body absorbs too much iron and hemochromatosis can result. Those who inherit the defective gene from only one parent are carriers for the disease but usually do not develop it; however, they still may have higher than average iron absorption. Neither juvenile hemochromatosis nor neonatal hemochromatosis are caused by an HFE defect. Juvenile and neonatal hemochromatosis are caused by a mutation in a gene called hemojuvelin.





    ان الطفولة فترة من العمر يعيش بها الانسان على حساب غيره


  2. #2
    عضو ذهبي الصورة الرمزية ماجده
    تاريخ التسجيل
    Aug 2011
    الدولة
    Jordan - Zerqa
    المشاركات
    902

    افتراضي

    thank u
    Majeda
    ##############

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